Assay Detail
Binding
CHEMBL4363628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of influenza A virus H3N2 clinical isolate neuraminidase using NA-Fluor MUNANA as substrate preincubated for 20 to 30 mins followed by substrate addition and measured for 60 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus H3N2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL6015) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Memphis/1/1971(H3N2)) |
Publication
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.16 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.96 |
| CHEMBL4545891 | — | — | 1 | 8.79 |
| CHEMBL4472001 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4545891 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL4472001 | — | IC50 | = | 1.92 | nM | 8.72 |