Assay Detail
Functional
CHEMBL4363864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A fluorine scan on the Zn<sup>2+</sup>-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.38 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4524784 | — | — | 1 | 5.42 |
| CHEMBL4470483 | — | — | 1 | 5.39 |
| CHEMBL1173445 | LARGAZOLE | — | 1 | 5.32 |
| CHEMBL4562992 | — | — | 1 | - |
| CHEMBL4513302 | — | — | 1 | - |
| CHEMBL4559417 | — | — | 1 | - |
| CHEMBL4435710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4524784 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4470483 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL4562992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4513302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4559417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435710 | — | IC50 | > | 10000.0 | nM | - |