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Assay Detail

CHEMBL4364113

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Functional
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.
Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.
Bioorg Med Chem (2019) 27 : 115144 -115144
PubMed 31653441 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.31 8.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4463093 1 8.02
CHEMBL4458551 1 8.00
CHEMBL4466050 1 7.99
CHEMBL4471854 1 7.99
CHEMBL4516892 1 7.98
CHEMBL4574434 1 7.27
CHEMBL4517788 1 7.00
CHEMBL1951578 1 6.98
CHEMBL4449191 1 6.94
CHEMBL107 COLCHICINE 4.0 1 6.90
CHEMBL53463 DOXORUBICIN 4.0 1 6.59
CHEMBL4530811 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4463093 IC50 = 9.6 nM 8.02
CHEMBL4458551 IC50 = 10.1 nM 8.00
CHEMBL4466050 IC50 = 10.2 nM 7.99
CHEMBL4471854 IC50 = 10.2 nM 7.99
CHEMBL4516892 IC50 = 10.5 nM 7.98
CHEMBL4574434 IC50 = 53.4 nM 7.27
CHEMBL4517788 IC50 = 99.1 nM 7.00
CHEMBL1951578 IC50 = 104.5 nM 6.98
CHEMBL4449191 IC50 = 114.9 nM 6.94
CHEMBL107 COLCHICINE IC50 = 125.2 nM 6.90
CHEMBL53463 DOXORUBICIN IC50 = 258.0 nM 6.59
CHEMBL4530811 IC50 = 880.9 nM 6.05