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Assay Detail

CHEMBL4364529

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of TO from EB virus g4-EBNA1 mRNA measured after 5 mins by FID assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human gammaherpesvirus 4
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel cationic bis(acylhydrazones) as modulators of Epstein-Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA.
Reznichenko O, Quillévéré A, Martins RP, Loaëc N, Kang H, Lista MJ, Beauvineau C, González-García J, Guillot R, Voisset C, Daskalogianni C, Fåhraeus R, Teulade-Fichou MP, Blondel M, Granzhan A.
Eur J Med Chem (2019) 178 : 13 -29
PubMed 31173968 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.21 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4460628 1 6.58
CHEMBL4441159 1 6.52
CHEMBL4530664 1 6.50
CHEMBL4434789 1 6.47
CHEMBL259739 1 6.46
CHEMBL4551309 1 6.41
CHEMBL4536468 1 6.23
CHEMBL4542381 1 6.21
CHEMBL4440570 1 6.19
CHEMBL4446740 1 6.15
CHEMBL4532992 1 6.14
CHEMBL4556166 1 6.13
CHEMBL4460497 1 6.13
CHEMBL4464051 1 6.10
CHEMBL4587498 1 6.03
CHEMBL4583442 1 5.96
CHEMBL4463973 1 5.91
CHEMBL4441941 1 5.63
CHEMBL4445207 1 -
CHEMBL4577555 1 -
CHEMBL4527796 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4460628 IC50 = 260.0 nM 6.58
CHEMBL4441159 IC50 = 300.0 nM 6.52
CHEMBL4530664 IC50 = 320.0 nM 6.50
CHEMBL4434789 IC50 = 340.0 nM 6.47
CHEMBL259739 IC50 = 350.0 nM 6.46
CHEMBL4551309 IC50 = 390.0 nM 6.41
CHEMBL4536468 IC50 = 590.0 nM 6.23
CHEMBL4542381 IC50 = 610.0 nM 6.21
CHEMBL4440570 IC50 = 650.0 nM 6.19
CHEMBL4446740 IC50 = 710.0 nM 6.15
CHEMBL4532992 IC50 = 720.0 nM 6.14
CHEMBL4556166 IC50 = 740.0 nM 6.13
CHEMBL4460497 IC50 = 740.0 nM 6.13
CHEMBL4464051 IC50 = 800.0 nM 6.10
CHEMBL4587498 IC50 = 930.0 nM 6.03
CHEMBL4583442 IC50 = 1090.0 nM 5.96
CHEMBL4463973 IC50 = 1240.0 nM 5.91
CHEMBL4441941 IC50 = 2320.0 nM 5.63
CHEMBL4445207 IC50 > 2500.0 nM -
CHEMBL4577555 IC50 > 2500.0 nM -
CHEMBL4527796 IC50 > 2500.0 nM -