Assay Detail

CHEMBL4365544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of ERK5 in human HeLa cells by KiNativ profiling method

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Mitogen-activated protein kinase 7 (CHEMBL5332) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Mitogen-activated protein kinase 7 (CHEMBL5332) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mitogen-activated protein kinase 7

CHEMBL5332

Anchored from Assay target.

Protein identity Mitogen-activated protein kinase 7

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	HeLa
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Mitogen-activated protein kinase 7 (CHEMBL5332) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C.
Eur J Med Chem (2019) 178 : 530 -543
PubMed 31212132 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.10	8.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4541479	—	—	1	8.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4541479	—	IC50	=	8.0	nM	8.10