Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4366089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.
Finlay HJ, Jiang J, Rampulla R, Salvati ME, Qiao JX, Wang TC, Lawrence RM, Harikrishnan LS, Kamau MG, Taylor DS, Chen AYA, Yin X, Huang CS, Chang M, Chen XQ, Sleph PG, Xu C, Li J, Levesque P, Adam LP, Wexler RR.
ACS Med Chem Lett (2019) 10 : 911 -916
PubMed 31223447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.68 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4439823 1 4.96
CHEMBL4552555 1 4.92
CHEMBL4545593 1 4.89
CHEMBL4468680 1 4.80
CHEMBL4436115 1 4.66
CHEMBL4457286 1 4.36
CHEMBL4452514 1 4.20
CHEMBL4448253 2 -
CHEMBL4473304 1 -
CHEMBL4468692 1 -
CHEMBL4574163 1 -
CHEMBL4439856 1 -
CHEMBL4469874 1 -
CHEMBL4475826 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4439823 IC50 = 11000.0 nM 4.96
CHEMBL4552555 IC50 = 12000.0 nM 4.92
CHEMBL4545593 IC50 = 13000.0 nM 4.89
CHEMBL4468680 IC50 = 16000.0 nM 4.80
CHEMBL4436115 IC50 = 22000.0 nM 4.66
CHEMBL4457286 IC50 = 44000.0 nM 4.36
CHEMBL4452514 IC50 = 63000.0 nM 4.20
CHEMBL4448253 IC50 > 80000.0 nM -
CHEMBL4448253 IC50 > 80000.0 nM -
CHEMBL4473304 IC50 > 80000.0 nM -
CHEMBL4468692 IC50 > 80000.0 nM -
CHEMBL4574163 IC50 > 80000.0 nM -
CHEMBL4439856 IC50 - -
CHEMBL4469874 IC50 - -
CHEMBL4475826 IC50 - -