Assay Detail
Binding
CHEMBL4366734
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Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate measured after 30 mins by fluorescence based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.71 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.51 |
| CHEMBL4446815 | — | — | 1 | 6.10 |
| CHEMBL3823220 | — | — | 1 | 5.96 |
| CHEMBL4466019 | — | — | 1 | 5.89 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.79 |
| CHEMBL4448344 | — | — | 1 | 5.75 |
| CHEMBL4579723 | — | — | 1 | 5.58 |
| CHEMBL4454576 | — | — | 1 | 5.54 |
| CHEMBL4591934 | — | — | 1 | 5.51 |
| CHEMBL4460825 | — | — | 1 | 5.48 |
| CHEMBL4563460 | — | — | 1 | 5.43 |
| CHEMBL4454566 | — | — | 1 | 5.34 |
| CHEMBL4565177 | — | — | 1 | 5.31 |
| CHEMBL4468771 | — | — | 1 | 5.28 |
| CHEMBL4448924 | — | — | 1 | 5.20 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4446815 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3823220 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4466019 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4448344 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4579723 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4454576 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4591934 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4460825 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4563460 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4454566 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4565177 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4468771 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4448924 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |