Assay Detail
Binding
CHEMBL4366762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT<sub>6</sub>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.01 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125735 | — | — | 1 | 8.52 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.15 |
| CHEMBL4520796 | — | — | 1 | 7.96 |
| CHEMBL4515075 | — | — | 1 | 7.72 |
| CHEMBL4447416 | — | — | 1 | 7.64 |
| CHEMBL4557247 | — | — | 1 | 7.58 |
| CHEMBL4570584 | — | — | 1 | 7.06 |
| CHEMBL4462404 | — | — | 1 | 6.96 |
| CHEMBL4522568 | — | — | 1 | 6.93 |
| CHEMBL4591878 | — | — | 1 | 6.90 |
| CHEMBL4473083 | — | — | 1 | 6.89 |
| CHEMBL4548041 | — | — | 1 | 6.89 |
| CHEMBL4524981 | — | — | 1 | 6.83 |
| CHEMBL4532712 | — | — | 1 | 6.68 |
| CHEMBL4584325 | — | — | 1 | 6.63 |
| CHEMBL4580959 | — | — | 1 | 6.62 |
| CHEMBL4527124 | — | — | 1 | 6.45 |
| CHEMBL4465929 | — | — | 1 | 6.29 |
| CHEMBL4560883 | — | — | 1 | 6.04 |
| CHEMBL4441655 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125735 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL715 | OLANZAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4520796 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4515075 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4447416 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4557247 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4570584 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL4462404 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL4522568 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL4591878 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL4473083 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL4548041 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL4524981 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL4532712 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL4584325 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL4580959 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL4527124 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL4465929 | — | Ki | = | 507.0 | nM | 6.29 |
| CHEMBL4560883 | — | Ki | = | 911.0 | nM | 6.04 |
| CHEMBL4441655 | — | Ki | = | 3574.0 | nM | 5.45 |