Assay Detail
Binding
CHEMBL4366763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-raclopride from human D2L receptor expressed in human HEK293 cells incubated for 1 hr by radioligand binding assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT<sub>6</sub>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.99 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.05 |
| CHEMBL4591878 | — | — | 1 | 6.48 |
| CHEMBL4580959 | — | — | 1 | 6.30 |
| CHEMBL4515075 | — | — | 1 | 6.28 |
| CHEMBL4522568 | — | — | 1 | 6.25 |
| CHEMBL4462404 | — | — | 1 | 6.18 |
| CHEMBL4524981 | — | — | 1 | 6.17 |
| CHEMBL4532712 | — | — | 1 | 6.13 |
| CHEMBL4557247 | — | — | 1 | 6.13 |
| CHEMBL4447416 | — | — | 1 | 6.00 |
| CHEMBL4520796 | — | — | 1 | 5.96 |
| CHEMBL4527124 | — | — | 1 | 5.91 |
| CHEMBL4473083 | — | — | 1 | 5.91 |
| CHEMBL4465929 | — | — | 1 | 5.87 |
| CHEMBL4548041 | — | — | 1 | 5.63 |
| CHEMBL4584325 | — | — | 1 | 5.54 |
| CHEMBL4570584 | — | — | 1 | 5.37 |
| CHEMBL4560883 | — | — | 1 | 5.36 |
| CHEMBL4441655 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4591878 | — | Ki | = | 329.0 | nM | 6.48 |
| CHEMBL4580959 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL4515075 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL4522568 | — | Ki | = | 566.0 | nM | 6.25 |
| CHEMBL4462404 | — | Ki | = | 656.0 | nM | 6.18 |
| CHEMBL4524981 | — | Ki | = | 674.0 | nM | 6.17 |
| CHEMBL4532712 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL4557247 | — | Ki | = | 734.0 | nM | 6.13 |
| CHEMBL4447416 | — | Ki | = | 1001.0 | nM | 6.00 |
| CHEMBL4520796 | — | Ki | = | 1094.0 | nM | 5.96 |
| CHEMBL4527124 | — | Ki | = | 1224.0 | nM | 5.91 |
| CHEMBL4473083 | — | Ki | = | 1234.0 | nM | 5.91 |
| CHEMBL4465929 | — | Ki | = | 1348.0 | nM | 5.87 |
| CHEMBL4548041 | — | Ki | = | 2362.0 | nM | 5.63 |
| CHEMBL4584325 | — | Ki | = | 2916.0 | nM | 5.54 |
| CHEMBL4570584 | — | Ki | = | 4247.0 | nM | 5.37 |
| CHEMBL4560883 | — | Ki | = | 4369.0 | nM | 5.36 |
| CHEMBL4441655 | — | Ki | = | 50140.0 | nM | 4.30 |