Assay Detail
Binding
CHEMBL4366765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Ketanserin from human 5-HT2A expressed in CHO-K1 cells incubated for 1.5 hrs by radioligand binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT<sub>6</sub>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.99 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527124 | — | — | 1 | 6.71 |
| CHEMBL4557247 | — | — | 1 | 6.71 |
| CHEMBL4462404 | — | — | 1 | 6.42 |
| CHEMBL4515075 | — | — | 1 | 6.39 |
| CHEMBL4580959 | — | — | 1 | 6.39 |
| CHEMBL4520796 | — | — | 1 | 6.37 |
| CHEMBL4522568 | — | — | 1 | 6.23 |
| CHEMBL4447416 | — | — | 1 | 5.74 |
| CHEMBL4532712 | — | — | 1 | 5.64 |
| CHEMBL4465929 | — | — | 1 | 5.58 |
| CHEMBL4441655 | — | — | 1 | 4.94 |
| CHEMBL4570584 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527124 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL4557247 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL4462404 | — | Ki | = | 376.0 | nM | 6.42 |
| CHEMBL4515075 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL4580959 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL4520796 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL4522568 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL4447416 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL4532712 | — | Ki | = | 2274.0 | nM | 5.64 |
| CHEMBL4465929 | — | Ki | = | 2628.0 | nM | 5.58 |
| CHEMBL4441655 | — | Ki | = | 11590.0 | nM | 4.94 |
| CHEMBL4570584 | — | Ki | = | 17170.0 | nM | 4.76 |