Assay Detail
Functional
CHEMBL4366792
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 4.81 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446230 | — | — | 1 | 5.57 |
| CHEMBL4466355 | — | — | 1 | 5.28 |
| CHEMBL4554243 | — | — | 1 | 5.20 |
| CHEMBL4450671 | — | — | 1 | 5.19 |
| CHEMBL4536844 | — | — | 1 | 5.18 |
| CHEMBL4564045 | — | — | 1 | 5.17 |
| CHEMBL4472487 | — | — | 1 | 5.16 |
| CHEMBL4448735 | — | — | 1 | 5.09 |
| CHEMBL4521837 | — | — | 1 | 5.08 |
| CHEMBL4467886 | — | — | 1 | 5.07 |
| CHEMBL4447411 | — | — | 1 | 5.00 |
| CHEMBL4588030 | — | — | 1 | 4.88 |
| CHEMBL4463420 | — | — | 1 | 4.83 |
| CHEMBL4568427 | — | — | 1 | 4.80 |
| CHEMBL16171 | WOGONIN | — | 1 | 4.75 |
| CHEMBL4544831 | — | — | 1 | 4.75 |
| CHEMBL4461927 | — | — | 1 | 4.75 |
| CHEMBL4567355 | — | — | 1 | 4.74 |
| CHEMBL4445339 | — | — | 1 | 4.66 |
| CHEMBL4464050 | — | — | 1 | 4.64 |
| CHEMBL4091366 | — | — | 1 | 4.60 |
| CHEMBL4462455 | — | — | 1 | 4.56 |
| CHEMBL4063519 | — | — | 1 | 4.47 |
| CHEMBL4463132 | — | — | 1 | 4.47 |
| CHEMBL4560755 | — | — | 1 | 4.42 |
| CHEMBL4454077 | — | — | 1 | 4.41 |
| CHEMBL2268880 | GALANGUSTIN | — | 1 | 4.37 |
| CHEMBL4099548 | — | — | 1 | 4.23 |
| CHEMBL4591454 | — | — | 1 | 4.11 |
| CHEMBL4471720 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446230 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4466355 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4554243 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4450671 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4536844 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4564045 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4472487 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4448735 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4521837 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4467886 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4447411 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4588030 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4463420 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4568427 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4461927 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL16171 | WOGONIN | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4544831 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4567355 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4445339 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4464050 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4091366 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL4462455 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4063519 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4463132 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL4560755 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL4454077 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL2268880 | GALANGUSTIN | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL4099548 | — | IC50 | = | 59400.0 | nM | 4.23 |
| CHEMBL4591454 | — | IC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL4471720 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4469747 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4461763 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4456104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4464420 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4445700 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4435682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4469440 | — | IC50 | > | 100000.0 | nM | - |