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Assay Detail

CHEMBL4366889

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
Aguilar A, Zheng K, Xu T, Xu S, Huang L, Fernandez-Salas E, Liu L, Bernard D, Harvey KP, Foster C, McEachern D, Stuckey J, Chinnaswamy K, Delproposto J, Kampf JW, Wang S.
J Med Chem (2019) 62 : 6015 -6034
PubMed 31244110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 5.79 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4449381 1 7.60
CHEMBL4458829 1 6.52
CHEMBL4516680 1 6.42
CHEMBL4576593 1 6.30
CHEMBL4436641 1 6.30
CHEMBL4568235 1 6.10
CHEMBL4585198 1 6.08
CHEMBL4459554 1 6.05
CHEMBL4522767 1 6.05
CHEMBL4551865 1 6.04
CHEMBL4449199 1 6.01
CHEMBL4467100 1 5.96
CHEMBL4578509 1 5.96
CHEMBL4470192 1 5.92
CHEMBL4476073 1 5.89
CHEMBL4446177 1 5.89
CHEMBL4448156 1 5.88
CHEMBL4592636 1 5.86
CHEMBL4448045 1 5.85
CHEMBL4444304 1 5.81
CHEMBL4532417 1 5.80
CHEMBL4581439 1 5.77
CHEMBL4453006 1 5.77
CHEMBL4570651 1 5.75
CHEMBL4460234 1 5.68
CHEMBL4452253 1 5.66
CHEMBL4466955 1 5.62
CHEMBL4474336 1 5.62
CHEMBL3126196 1 5.44
CHEMBL4565646 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4449381 IC50 = 25.0 nM 7.60
CHEMBL4458829 IC50 = 300.0 nM 6.52
CHEMBL4516680 IC50 = 380.0 nM 6.42
CHEMBL4576593 IC50 = 500.0 nM 6.30
CHEMBL4436641 IC50 = 500.0 nM 6.30
CHEMBL4568235 IC50 = 800.0 nM 6.10
CHEMBL4585198 IC50 = 840.0 nM 6.08
CHEMBL4459554 IC50 = 900.0 nM 6.05
CHEMBL4522767 IC50 = 900.0 nM 6.05
CHEMBL4551865 IC50 = 910.0 nM 6.04
CHEMBL4449199 IC50 = 980.0 nM 6.01
CHEMBL4467100 IC50 = 1100.0 nM 5.96
CHEMBL4578509 IC50 = 1100.0 nM 5.96
CHEMBL4470192 IC50 = 1200.0 nM 5.92
CHEMBL4446177 IC50 = 1300.0 nM 5.89
CHEMBL4476073 IC50 = 1300.0 nM 5.89
CHEMBL4448156 IC50 = 1330.0 nM 5.88
CHEMBL4592636 IC50 = 1370.0 nM 5.86
CHEMBL4448045 IC50 = 1400.0 nM 5.85
CHEMBL4444304 IC50 = 1550.0 nM 5.81
CHEMBL4532417 IC50 = 1570.0 nM 5.80
CHEMBL4581439 IC50 = 1700.0 nM 5.77
CHEMBL4453006 IC50 = 1700.0 nM 5.77
CHEMBL4570651 IC50 = 1800.0 nM 5.75
CHEMBL4460234 IC50 = 2100.0 nM 5.68
CHEMBL4452253 IC50 = 2200.0 nM 5.66
CHEMBL4466955 IC50 = 2400.0 nM 5.62
CHEMBL4474336 IC50 = 2400.0 nM 5.62
CHEMBL3126196 IC50 = 3600.0 nM 5.44
CHEMBL4565646 IC50 = 3900.0 nM 5.41
CHEMBL4528850 IC50 = 3960.0 nM 5.40
CHEMBL4457683 IC50 = 4300.0 nM 5.37
CHEMBL4592512 IC50 = 4430.0 nM 5.35
CHEMBL4537683 IC50 = 6330.0 nM 5.20
CHEMBL4515980 IC50 = 10300.0 nM 4.99
CHEMBL4453547 IC50 = 10700.0 nM 4.97
CHEMBL4462347 IC50 = 14300.0 nM 4.84
CHEMBL4533602 IC50 = 16900.0 nM 4.77