Assay Detail
Functional
CHEMBL4367123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-based microscopic analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.75 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107800 | — | — | 1 | 6.96 |
| CHEMBL675 | ALENDRONATE SODIUM | 4.0 | 1 | 5.43 |
| CHEMBL4472578 | — | — | 1 | 5.23 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | 5.12 |
| CHEMBL75390 | — | — | 1 | 5.11 |
| CHEMBL4533585 | — | — | 1 | 5.08 |
| CHEMBL4452745 | — | — | 1 | 4.82 |
| CHEMBL4559591 | — | — | 1 | 4.82 |
| CHEMBL222021 | PROTOCATECHUALDEHYDE | — | 1 | 4.82 |
| CHEMBL4580235 | — | — | 1 | 4.75 |
| CHEMBL4455945 | — | — | 1 | 4.72 |
| CHEMBL4593236 | — | — | 1 | 4.62 |
| CHEMBL4438319 | — | — | 1 | 4.60 |
| CHEMBL9184 | — | — | 1 | 4.50 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.39 |
| CHEMBL249450 | — | — | 1 | 4.32 |
| CHEMBL1284 | 3,4-DIHYDROXYPHENYLACETIC ACID | — | 1 | 4.12 |
| CHEMBL486027 | METHYL PROTOCATECHUATE | — | 1 | 4.11 |
| CHEMBL3120494 | — | — | 1 | 4.10 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | 4.07 |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | 4.05 |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL1044 | PHENYLACETIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107800 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL675 | ALENDRONATE SODIUM | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4472578 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL106509 | DEHYDROZINGERONE | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL75390 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4533585 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4452745 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4559591 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL222021 | PROTOCATECHUALDEHYDE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4580235 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4455945 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4593236 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4438319 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL9184 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL249450 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1284 | 3,4-DIHYDROXYPHENYLACETIC ACID | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL486027 | METHYL PROTOCATECHUATE | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3120494 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL37537 | PROTOCATECHUIC ACID | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL27246 | CINNAMIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL1044 | PHENYLACETIC ACID | IC50 | > | 100000.0 | nM | - |