Assay Detail
Binding
CHEMBL4367180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of isopentenyl diphosphate isomerase in Sprague-Dawley rat liver S100 fraction preincubated for 10 min followed by MVA addition by HPLC analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | S100 Fraction |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isopentenyl-diphosphate Delta-isomerase 1 (CHEMBL4523132) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.77 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL675 | ALENDRONATE SODIUM | 4.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL675 | ALENDRONATE SODIUM | IC50 | = | 1700.0 | nM | 5.77 |