Assay Detail
Binding
CHEMBL4367183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of farnesyl diphosphate synthase in Balb/C mouse osteoclast assessed as reduction in [3H]MVL incorporation into prenylated proteins preincubated for 2 hrs followed by [3H]MVL addition and measured after 4 hrs by SDS-gel electrophoresis method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.82 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL675 | ALENDRONATE SODIUM | 4.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL675 | ALENDRONATE SODIUM | IC50 | = | 15000.0 | nM | 4.82 |