Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4367227

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
ChEMBL ↗
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents.
Zhang J, Zhang J, Hao G, Xin W, Yang F, Zhu M, Zhou H.
J Med Chem (2019) 62 : 6765 -6784
PubMed 31264855 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 5.65 8.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 8.16
CHEMBL4435222 — — 1 7.43
CHEMBL4472291 — — 1 7.40
CHEMBL4453371 — — 1 7.28
CHEMBL4446637 — — 1 7.25
CHEMBL4568921 — — 1 7.06
CHEMBL4470595 — — 1 6.96
CHEMBL4452059 — — 1 6.85
CHEMBL4567927 — — 1 6.82
CHEMBL4470776 — — 1 6.82
CHEMBL4483672 — — 1 6.66
CHEMBL4540815 — — 1 6.64
CHEMBL4590818 — — 1 6.60
CHEMBL4516780 — — 1 6.60
CHEMBL4474053 — — 1 6.58
CHEMBL4455689 — — 1 6.42
CHEMBL4573676 — — 1 6.39
CHEMBL4459423 — — 1 6.36
CHEMBL4563761 — — 1 6.34
CHEMBL4447707 — — 1 6.29
CHEMBL4570499 — — 1 6.24
CHEMBL4470086 — — 1 6.19
CHEMBL4543237 — — 1 6.14
CHEMBL4571442 — — 1 6.07
CHEMBL4554022 — — 1 6.06
CHEMBL4445066 — — 1 6.03
CHEMBL4441329 — — 1 5.96
CHEMBL4442237 — — 1 5.89
CHEMBL4518254 — — 1 5.89
CHEMBL4551706 — — 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 6.9 nM 8.16
CHEMBL4435222 — IC50 = 37.0 nM 7.43
CHEMBL4472291 — IC50 = 40.0 nM 7.40
CHEMBL4453371 — IC50 = 52.0 nM 7.28
CHEMBL4446637 — IC50 = 56.0 nM 7.25
CHEMBL4568921 — IC50 = 88.0 nM 7.06
CHEMBL4470595 — IC50 = 110.0 nM 6.96
CHEMBL4452059 — IC50 = 140.0 nM 6.85
CHEMBL4567927 — IC50 = 150.0 nM 6.82
CHEMBL4470776 — IC50 = 150.0 nM 6.82
CHEMBL4483672 — IC50 = 220.0 nM 6.66
CHEMBL4540815 — IC50 = 230.0 nM 6.64
CHEMBL4590818 — IC50 = 250.0 nM 6.60
CHEMBL4516780 — IC50 = 250.0 nM 6.60
CHEMBL4474053 — IC50 = 260.0 nM 6.58
CHEMBL4455689 — IC50 = 380.0 nM 6.42
CHEMBL4573676 — IC50 = 410.0 nM 6.39
CHEMBL4459423 — IC50 = 440.0 nM 6.36
CHEMBL4563761 — IC50 = 460.0 nM 6.34
CHEMBL4447707 — IC50 = 510.0 nM 6.29
CHEMBL4570499 — IC50 = 570.0 nM 6.24
CHEMBL4470086 — IC50 = 640.0 nM 6.19
CHEMBL4543237 — IC50 = 720.0 nM 6.14
CHEMBL4571442 — IC50 = 850.0 nM 6.07
CHEMBL4554022 — IC50 = 870.0 nM 6.06
CHEMBL4445066 — IC50 = 930.0 nM 6.03
CHEMBL4441329 — IC50 = 1100.0 nM 5.96
CHEMBL4442237 — IC50 = 1300.0 nM 5.89
CHEMBL4518254 — IC50 = 1300.0 nM 5.89
CHEMBL4551706 — IC50 = 1600.0 nM 5.80
CHEMBL4440696 — IC50 = 1600.0 nM 5.80
CHEMBL4473624 — IC50 = 1800.0 nM 5.75
CHEMBL4469474 — IC50 = 2700.0 nM 5.57
CHEMBL4537197 — IC50 = 3600.0 nM 5.44
CHEMBL4514576 — IC50 = 5300.0 nM 5.28
CHEMBL4465090 — IC50 = 5300.0 nM 5.28
CHEMBL4568275 — IC50 = 6600.0 nM 5.18
CHEMBL4476577 — IC50 = 8800.0 nM 5.06
CHEMBL4467718 — IC50 = 12000.0 nM 4.92
CHEMBL4558241 — IC50 = 18000.0 nM 4.75
CHEMBL4438275 — IC50 = 21000.0 nM 4.68
CHEMBL4526137 — IC50 = 25000.0 nM 4.60
CHEMBL4449365 — IC50 = 29000.0 nM 4.54
CHEMBL4458796 — IC50 = 29000.0 nM 4.54
CHEMBL4444670 — IC50 = 33000.0 nM 4.48
CHEMBL4465334 — IC50 = 33000.0 nM 4.48
CHEMBL4461793 — IC50 = 36000.0 nM 4.44
CHEMBL4435649 — IC50 = 41000.0 nM 4.39
CHEMBL4467599 — IC50 = 49000.0 nM 4.31
CHEMBL4593971 — IC50 = 52000.0 nM 4.28