Assay Detail
Binding
CHEMBL4367272
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Inhibition of human ERG
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.52 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4570289 | — | — | 1 | 4.88 |
| CHEMBL4550278 | — | — | 1 | 4.80 |
| CHEMBL3753837 | — | — | 1 | 4.64 |
| CHEMBL4450473 | — | — | 1 | 4.52 |
| CHEMBL4517185 | — | — | 1 | 4.47 |
| CHEMBL4543526 | — | — | 1 | 4.19 |
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 1 | 4.15 |
| CHEMBL4576829 | — | — | 1 | - |
| CHEMBL4461858 | — | — | 1 | - |
| CHEMBL4562289 | — | — | 1 | - |
| CHEMBL4540038 | — | — | 1 | - |
| CHEMBL4535605 | — | — | 1 | - |
| CHEMBL4530496 | — | — | 1 | - |
| CHEMBL4467206 | — | — | 1 | - |
| CHEMBL4476312 | — | — | 1 | - |
| CHEMBL4446572 | — | — | 1 | - |
| CHEMBL4435301 | — | — | 1 | - |
| CHEMBL4443852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4570289 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4550278 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3753837 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4450473 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4517185 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4543526 | — | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3989951 | NAVOXIMOD | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4576829 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4461858 | — | EC50 | - | — | - | |
| CHEMBL4562289 | — | EC50 | - | — | - | |
| CHEMBL4540038 | — | EC50 | - | — | - | |
| CHEMBL4535605 | — | EC50 | - | — | - | |
| CHEMBL4530496 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4467206 | — | EC50 | - | — | - | |
| CHEMBL4476312 | — | EC50 | - | — | - | |
| CHEMBL4446572 | — | EC50 | - | — | - | |
| CHEMBL4435301 | — | EC50 | - | — | - | |
| CHEMBL4443852 | — | EC50 | - | — | - |