Assay Detail
Functional
CHEMBL4367471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in ulcerative colitis patient derived inflamed intestinal mucosa assessed as reduction in IL6 production measured after overnight incubation by immunoassay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Intestinal mucosa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| IC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4514780 | — | — | 2 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4514780 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4514780 | — | Activity | - | — | - |