Assay Detail
Binding
CHEMBL4367477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOD2/TLR2 in human PBMC assessed as reduction in MDP/Pam2CSK4-induced TNFalpha production preincubated for 30 mins followed by MDP/Pam2CSK4 stimulation and measured after 6 hrs by immunoassay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822577 | — | — | 2 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822577 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3822577 | — | Inhibition | - | % | - |