Assay Detail
Functional
CHEMBL4367791
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Antileishmanial activity against intracellular amastigote stage of Leishmania braziliensis MHOM/IT/2006/ISS2848 assessed as reduction in parasite viability measured after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania braziliensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.35 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.70 |
| CHEMBL4217754 | — | — | 1 | 6.30 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4217754 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 890.0 | nM | 6.05 |