Assay Detail
Binding
CHEMBL4367858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of soyabean 15-LOX preincubated for 5 mins followed by susbtrate addition measured after 10 mins by colorimetric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.96 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 7.41 |
| CHEMBL4456822 | — | — | 1 | 7.18 |
| CHEMBL4438795 | — | — | 1 | 7.08 |
| CHEMBL4591824 | — | — | 1 | 6.68 |
| CHEMBL4444717 | — | — | 1 | 6.47 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | IC50 | = | 38.91 | nM | 7.41 |
| CHEMBL4456822 | — | IC50 | = | 66.14 | nM | 7.18 |
| CHEMBL4438795 | — | IC50 | = | 83.54 | nM | 7.08 |
| CHEMBL4591824 | — | IC50 | = | 209.5 | nM | 6.68 |
| CHEMBL4444717 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL6 | INDOMETHACIN | IC50 | - | — | - | |
| CHEMBL118 | CELECOXIB | IC50 | - | — | - |