Assay Detail
Binding
CHEMBL4367920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluorescence based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.36 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.55 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.87 |
| CHEMBL4538762 | — | — | 1 | 5.32 |
| CHEMBL4456222 | — | — | 1 | 5.28 |
| CHEMBL4567417 | — | — | 1 | 5.19 |
| CHEMBL4434713 | — | — | 1 | 5.17 |
| CHEMBL4441838 | — | — | 1 | 5.15 |
| CHEMBL4573947 | — | — | 1 | 5.02 |
| CHEMBL4574317 | — | — | 1 | 4.97 |
| CHEMBL4457588 | — | — | 1 | 4.90 |
| CHEMBL4473943 | — | — | 1 | 4.57 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4538762 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4456222 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4567417 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4434713 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4441838 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4573947 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4574317 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4457588 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4473943 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |