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Assay Detail

CHEMBL4368751

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H] spiperone from human D2 dopamine receptor expressed in monkey caudate-putamen membranes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Caudate-putamen
Subcellular Membranes
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Divalent cannabinoid-1 receptor ligands: A linker attachment point survey of SR141716A for development of high-affinity CB1R molecular probes.
Grant PS, Kahlcke N, Govindpani K, Hunter M, MacDonald C, Brimble MA, Glass M, Furkert DP.
Bioorg Med Chem Lett (2019) 29 : 126644 -126644
PubMed 31564385 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.88 7.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109684 1 7.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109684 Ki = 13.3 nM 7.88