Assay Detail

CHEMBL4369002

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Functional

Induction of apoptosis in human ibrutinib-resistant Z138 cells after 48 hrs by Annexin-V/propidium iodide staining based assay

ChEMBL ↗

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Target

Z-138 (CHEMBL4483276) ↗

Open DB target context

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Primary target Z-138

CHEMBL4483276

Anchored from Assay target.

Protein identity Z-138

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Z-138
Confidence	1 — Organism
Curated By	Autocuration

Target

Z-138 (CHEMBL4483276) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Targeting Brd4 for cancer therapy: inhibitors and degraders.

Duan Y, Guan Y, Qin W, Zhai X, Yu B, Liu H.
Medchemcomm (2018) 9 : 1779 -1802
PubMed 30542529 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.67	6.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4215078	—	—	1	6.85
CHEMBL4470094	—	—	1	6.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4215078	—	IC50	=	142.0	nM	6.85
CHEMBL4470094	—	IC50	=	327.0	nM	6.49