Assay Detail
Binding
CHEMBL4369112
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Displacement of [3H]-LSD from recombinant human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.33 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216263 | — | — | 1 | 5.78 |
| CHEMBL4544802 | — | — | 1 | 5.22 |
| CHEMBL4474827 | — | — | 1 | 5.16 |
| CHEMBL4517552 | — | — | 1 | 5.14 |
| CHEMBL4469847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216263 | — | Ki | = | 1673.0 | nM | 5.78 |
| CHEMBL4544802 | — | Ki | = | 6062.0 | nM | 5.22 |
| CHEMBL4474827 | — | Ki | = | 6910.0 | nM | 5.16 |
| CHEMBL4517552 | — | Ki | = | 7271.0 | nM | 5.14 |
| CHEMBL4469847 | — | Ki | > | 10000.0 | nM | - |