Assay Detail
ADMET
CHEMBL4369192
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 5.23 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 6.40 |
| CHEMBL3115821 | — | — | 1 | 6.10 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 5.92 |
| CHEMBL2098184 | — | — | 1 | 5.58 |
| CHEMBL1230468 | — | — | 1 | 5.55 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 5.40 |
| CHEMBL3637864 | — | — | 1 | 5.32 |
| CHEMBL2098293 | — | — | 1 | 5.29 |
| CHEMBL536806 | — | — | 1 | 5.27 |
| CHEMBL530887 | — | — | 1 | 5.18 |
| CHEMBL3637896 | — | — | 1 | 5.12 |
| CHEMBL526813 | — | — | 1 | 5.12 |
| CHEMBL1397830 | — | — | 1 | 5.08 |
| CHEMBL580032 | — | — | 1 | 5.05 |
| CHEMBL3637905 | — | — | 1 | 5.00 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.00 |
| CHEMBL238442 | — | — | 1 | 4.96 |
| CHEMBL525292 | — | — | 1 | 4.92 |
| CHEMBL545853 | — | — | 1 | 4.89 |
| CHEMBL565436 | — | — | 1 | 4.82 |
| CHEMBL1836611 | — | — | 1 | 4.82 |
| CHEMBL413331 | — | — | 1 | 4.77 |
| CHEMBL2109740 | — | — | 1 | 4.66 |
| CHEMBL1367316 | — | — | 1 | - |
| CHEMBL3637920 | — | — | 1 | - |
| CHEMBL528061 | — | — | 1 | - |
| CHEMBL534797 | — | — | 1 | - |
| CHEMBL2109928 | — | — | 1 | - |
| CHEMBL2313136 | — | — | 1 | - |
| CHEMBL2109769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3115821 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2098184 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1230468 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3637864 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2098293 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL536806 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL530887 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3637896 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL526813 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1397830 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL580032 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3637905 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL238442 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL525292 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL545853 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1836611 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL565436 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL413331 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2109740 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL528966 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637922 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637845 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL86754 | IODOQUINOL | IC50 | > | 25000.0 | nM | - |
| CHEMBL532369 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL402548 | DANUSERTIB | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637898 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3431330 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3431272 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1872842 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3546548 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1197563 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3431294 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL139814 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2030556 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637926 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637885 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL88430 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3637867 | — | IC50 | - | — | - | |
| CHEMBL3637783 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2109769 | — | IC50 | - | — | - | |
| CHEMBL2313136 | — | IC50 | - | — | - | |
| CHEMBL2109928 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL534797 | — | IC50 | - | — | - | |
| CHEMBL528061 | — | IC50 | - | — | - | |
| CHEMBL3637920 | — | IC50 | - | — | - | |
| CHEMBL1367316 | — | IC50 | - | — | - |