Assay Detail
Binding
CHEMBL4369205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PNP using inosine as substrate by xanthine oxidase coupled assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The transition to magic bullets - transition state analogue drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.37 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473922 | — | — | 1 | 10.38 |
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 10.25 |
| CHEMBL1236524 | GALIDESIVIR | 2.0 | 1 | 7.48 |
| CHEMBL505564 | — | — | 1 | - |
| CHEMBL4578463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473922 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL218291 | FORODESINE | Ki | = | 0.056 | nM | 10.25 |
| CHEMBL1236524 | GALIDESIVIR | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL505564 | — | Ki | = | 0.0052 | nM | - |
| CHEMBL4578463 | — | Ki | = | 0.0086 | nM | - |