Assay Detail
Binding
CHEMBL4369236
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Inhibition of human carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.47 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179559 | — | — | 1 | 9.92 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 9.60 |
| CHEMBL4473329 | — | — | 1 | 9.52 |
| CHEMBL1370332 | — | — | 1 | 9.33 |
| CHEMBL2298035 | — | — | 1 | 9.32 |
| CHEMBL2392423 | — | — | 1 | 8.54 |
| CHEMBL3290513 | — | — | 1 | 8.47 |
| CHEMBL2298033 | — | — | 1 | 8.38 |
| CHEMBL3237495 | — | — | 1 | 8.36 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.11 |
| CHEMBL3237492 | — | — | 1 | 7.72 |
| CHEMBL4538894 | — | — | 1 | 7.59 |
| CHEMBL4584443 | — | — | 1 | 7.59 |
| CHEMBL3237494 | — | — | 1 | 7.37 |
| CHEMBL4456875 | — | — | 1 | 7.26 |
| CHEMBL4447505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179559 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL18 | ETHOXZOLAMIDE | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4473329 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1370332 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL2298035 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL2392423 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL3290513 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL2298033 | — | IC50 | = | 4.14 | nM | 8.38 |
| CHEMBL3237495 | — | IC50 | = | 4.42 | nM | 8.36 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 7.72 | nM | 8.11 |
| CHEMBL3237492 | — | IC50 | = | 18.98 | nM | 7.72 |
| CHEMBL4538894 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL4584443 | — | IC50 | = | 25.75 | nM | 7.59 |
| CHEMBL3237494 | — | IC50 | = | 42.23 | nM | 7.37 |
| CHEMBL4456875 | — | IC50 | = | 54.35 | nM | 7.26 |
| CHEMBL4447505 | — | IC50 | > | 104.0 | nM | - |