Assay Detail
Binding
CHEMBL4369243
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Inhibition of MAOA (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.06 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.15 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 6.04 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 5.88 |
| CHEMBL241902 | — | — | 1 | 5.74 |
| CHEMBL398206 | — | — | 1 | 5.30 |
| CHEMBL1096480 | — | — | 1 | 5.22 |
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | - |
| CHEMBL2369206 | — | — | 1 | - |
| CHEMBL393467 | — | — | 1 | - |
| CHEMBL1818874 | — | — | 1 | - |
| CHEMBL1818875 | — | — | 1 | - |
| CHEMBL1910220 | — | — | 1 | - |
| CHEMBL391982 | — | — | 1 | - |
| CHEMBL193804 | — | — | 1 | - |
| CHEMBL1096479 | — | — | 1 | - |
| CHEMBL242113 | — | — | 1 | - |
| CHEMBL243185 | PHENYLTHIOSEMICARBAZONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL673 | PARGYLINE | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL241902 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL398206 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL1096480 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL279390 | LAZABEMIDE | IC50 | > | 80000.0 | nM | - |
| CHEMBL2369206 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL393467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1818874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1818875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1910220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL391982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL193804 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243185 | PHENYLTHIOSEMICARBAZONE | IC50 | > | 10000.0 | nM | - |