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Assay Detail

CHEMBL4369246

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of MAOA (unknown origin) using varying levels of kynuramine as substrate preincubated for 15 mins followed by substrate addition and measured by Lineweaver-burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.
Mathew B, Baek SC, Grace Thomas Parambi D, Pil Lee J, Joy M, Annie Rilda PR, Randev RV, Nithyamol P, Vijayan V, Inasu ST, Mathew GE, Lohidakshan KK, Kumar Krishnan G, Kim H.
Medchemcomm (2018) 9 : 1871 -1881
PubMed 30568755 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.01 6.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL241902 1 6.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL241902 Ki = 970.0 nM 6.01