Assay Detail
Binding
CHEMBL4369503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK2 (unknown origin) using PDC E1 as substrate measured after 30 mins by kinase-glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (CHEMBL3861) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent pyruvate dehydrogenase kinase inhibitors and evaluation of their anti-lung cancer activity under hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.97 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3727577 | — | — | 1 | 6.89 |
| CHEMBL4586099 | — | — | 1 | 5.82 |
| CHEMBL4452464 | — | — | 1 | 5.60 |
| CHEMBL4450236 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3727577 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4586099 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4452464 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4450236 | — | IC50 | = | 2600.0 | nM | 5.58 |