Assay Detail
Binding
CHEMBL4369748
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Inhibition of mushroom tyrosinase monophenolase activity using L-tyrosine as substrate
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazones with tyrosinase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 5.81 |
| Ki | 1 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241902 | — | — | 1 | 5.81 |
| CHEMBL254119 | — | — | 1 | 5.75 |
| CHEMBL391982 | — | — | 1 | 5.17 |
| CHEMBL239452 | — | — | 1 | 4.81 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241902 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL254119 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL391982 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL239452 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL287556 | KOJIC ACID | Ki | = | 30000.0 | nM | 4.52 |