Assay Detail
Binding
CHEMBL4369750
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Inhibition of mushroom tyrosinase using L-dopa as substrate preincubated for 10 mins followed by substrate addition and measured for 1 min
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazones with tyrosinase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.00 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243127 | — | — | 1 | 6.75 |
| CHEMBL1910220 | — | — | 1 | 6.55 |
| CHEMBL4441726 | — | — | 1 | 6.48 |
| CHEMBL4470474 | — | — | 1 | 6.47 |
| CHEMBL4550716 | — | — | 1 | 6.43 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | — | 1 | 6.42 |
| CHEMBL242113 | — | — | 1 | 6.39 |
| CHEMBL4474510 | — | — | 1 | 6.39 |
| CHEMBL4528307 | — | — | 1 | 6.28 |
| CHEMBL4566829 | — | — | 1 | 6.12 |
| CHEMBL3191540 | — | — | 1 | 6.05 |
| CHEMBL4450054 | — | — | 1 | 6.04 |
| CHEMBL4583728 | — | — | 1 | 6.03 |
| CHEMBL4459329 | — | — | 1 | 6.01 |
| CHEMBL4464035 | — | — | 1 | 5.96 |
| CHEMBL4537252 | — | — | 1 | 5.89 |
| CHEMBL4469161 | — | — | 1 | 5.88 |
| CHEMBL339916 | — | — | 1 | 5.84 |
| CHEMBL398206 | — | — | 1 | 5.83 |
| CHEMBL3190453 | — | — | 1 | 5.72 |
| CHEMBL4554824 | — | — | 1 | 5.66 |
| CHEMBL4569745 | — | — | 1 | 5.52 |
| CHEMBL390625 | — | — | 1 | 5.41 |
| CHEMBL242103 | — | — | 1 | 5.31 |
| CHEMBL242104 | — | — | 1 | 5.25 |
| CHEMBL241893 | — | — | 1 | 5.19 |
| CHEMBL4578108 | — | — | 1 | - |
| CHEMBL243187 | — | — | 1 | - |
| CHEMBL4544091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243127 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1910220 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4441726 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4470474 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4550716 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL242113 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4474510 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4528307 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4566829 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3191540 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4450054 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4583728 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4459329 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4464035 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4537252 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4469161 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL339916 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL398206 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL3190453 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4554824 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4569745 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL390625 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL242103 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL242104 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL241893 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4578108 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL243187 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4544091 | — | IC50 | > | 30000.0 | nM | - |