Assay Detail

CHEMBL4369764

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Binding

Reversible competitive inhibition of mushroom tyrosinase after 10 mins by Lineweaver-Burk plot analysis

ChEMBL ↗

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Target

Tyrosinase (CHEMBL3318) ↗

Open DB target context

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Tyrosinase (CHEMBL3318) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosinase

CHEMBL3318

Anchored from Assay target.

Protein identity Tyrosinase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Agaricus bisporus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosinase (CHEMBL3318) ↗

Type	SINGLE PROTEIN
Organism	Agaricus bisporus

Publication

Thiosemicarbazones with tyrosinase inhibitory activity.

Hałdys K, Latajka R.
Medchemcomm (2019) 10 : 378 -389
PubMed 31015905 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.42	6.42

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL74689	PHENYL(METHYL)THIOSEMICARBAZONE	—	1	6.42

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL74689	PHENYL(METHYL)THIOSEMICARBAZONE	Ki	=	380.0	nM	6.42