Assay Detail
Binding
CHEMBL4369765
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Reversible mixed-type inhibition of mushroom tyrosinase using L-dopa as substrate by Lineweaver-Burk plot analysis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazones with tyrosinase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.66 | 7.10 |
| Kis | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818877 | — | — | 2 | 7.10 |
| CHEMBL1818876 | — | — | 2 | 6.22 |
| CHEMBL4562624 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818877 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1818876 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL1818877 | — | Kis | = | 0.29 | uM | - |
| CHEMBL1818876 | — | Kis | = | 1.18 | uM | - |
| CHEMBL4562624 | — | Ki | = | 167000.0 | nM | - |
| CHEMBL4562624 | — | Kis | = | 2.59 | uM | - |