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Assay Detail

CHEMBL4369804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A549 cells after 5 days by EZMTT reagent-based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity.
Chen Z, Li D, Xu N, Fang J, Yu Y, Hou W, Ruan H, Zhu P, Ma R, Lu S, Cao D, Wu R, Ni M, Zhang W, Su W, Ruan BH.
J Med Chem (2019) 62 : 589 -603
PubMed 30543285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.65 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4462204 1 8.00
CHEMBL4475144 1 7.77
CHEMBL4469040 1 7.77
CHEMBL3639788 TELAGLENASTAT 2.0 1 7.40
CHEMBL4474767 1 6.96
CHEMBL4566474 1 6.64
CHEMBL2177757 1 6.38
CHEMBL4474779 1 6.34
CHEMBL4451104 1 6.00
CHEMBL4442957 1 5.66
CHEMBL3669907 1 5.54
CHEMBL4590724 1 5.30
CHEMBL4550553 1 -
CHEMBL4465855 1 -
CHEMBL2178396 1 -
CHEMBL3664910 1 -
CHEMBL4441674 1 -
CHEMBL4441375 1 -
CHEMBL4436915 1 -
CHEMBL4522431 1 -
CHEMBL2178393 1 -
CHEMBL4582249 1 -
CHEMBL4565066 1 -
CHEMBL4593057 1 -
CHEMBL4459382 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4462204 IC50 = 10.0 nM 8.00
CHEMBL4475144 IC50 = 17.0 nM 7.77
CHEMBL4469040 IC50 = 17.0 nM 7.77
CHEMBL3639788 TELAGLENASTAT IC50 = 40.0 nM 7.40
CHEMBL4474767 IC50 = 110.0 nM 6.96
CHEMBL4566474 IC50 = 230.0 nM 6.64
CHEMBL2177757 IC50 = 420.0 nM 6.38
CHEMBL4474779 IC50 = 460.0 nM 6.34
CHEMBL4451104 IC50 = 1000.0 nM 6.00
CHEMBL4442957 IC50 = 2200.0 nM 5.66
CHEMBL3669907 IC50 = 2900.0 nM 5.54
CHEMBL4590724 IC50 = 5000.0 nM 5.30
CHEMBL4550553 IC50 > 13000.0 nM -
CHEMBL4465855 IC50 > 13000.0 nM -
CHEMBL2178396 IC50 > 13000.0 nM -
CHEMBL3664910 IC50 > 13000.0 nM -
CHEMBL4441674 IC50 > 13000.0 nM -
CHEMBL4441375 IC50 > 13000.0 nM -
CHEMBL4436915 IC50 > 13000.0 nM -
CHEMBL4522431 IC50 > 13000.0 nM -
CHEMBL2178393 IC50 > 13000.0 nM -
CHEMBL4582249 IC50 > 13000.0 nM -
CHEMBL4565066 IC50 > 13000.0 nM -
CHEMBL4593057 IC50 > 13000.0 nM -
CHEMBL4459382 IC50 > 13000.0 nM -