Assay Detail
Binding
CHEMBL4369833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.28 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517399 | — | — | 1 | 8.90 |
| CHEMBL425281 | — | — | 1 | 8.89 |
| CHEMBL4463042 | — | — | 1 | 8.57 |
| CHEMBL4475293 | — | — | 1 | 8.52 |
| CHEMBL4456830 | — | — | 1 | 8.47 |
| CHEMBL4556887 | — | — | 1 | 8.44 |
| CHEMBL2170781 | — | — | 1 | 8.43 |
| CHEMBL4541252 | — | — | 1 | 8.19 |
| CHEMBL4581511 | — | — | 1 | 7.26 |
| CHEMBL501261 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517399 | — | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL425281 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL4463042 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4475293 | — | Ki | = | 3.05 | nM | 8.52 |
| CHEMBL4456830 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4556887 | — | Ki | = | 3.66 | nM | 8.44 |
| CHEMBL2170781 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4541252 | — | Ki | = | 6.45 | nM | 8.19 |
| CHEMBL4581511 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL501261 | — | Ki | = | 76.7 | nM | 7.12 |