Assay Detail
Functional
CHEMBL4370154
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Antiproliferative activity against human OPM2 cells after 72 hrs by CellTiter-Glo luminescent assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OPM-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.16 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568404 | — | — | 1 | 6.18 |
| CHEMBL3979678 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568404 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL3979678 | — | IC50 | = | 720.0 | nM | 6.14 |