Assay Detail
Binding
CHEMBL4370193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 to 20 mins followed by substrate addition and measured every 1 min for 8 mins
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 5.46 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559294 | — | — | 1 | 6.43 |
| CHEMBL4516514 | — | — | 1 | 6.34 |
| CHEMBL4543065 | — | — | 1 | 6.32 |
| CHEMBL4539074 | — | — | 1 | 6.30 |
| CHEMBL4457949 | — | — | 1 | 6.27 |
| CHEMBL4571524 | — | — | 1 | 6.23 |
| CHEMBL4573731 | — | — | 1 | 6.19 |
| CHEMBL4466017 | — | — | 1 | 6.14 |
| CHEMBL4532036 | — | — | 1 | 6.10 |
| CHEMBL4514413 | — | — | 1 | 6.10 |
| CHEMBL4580349 | — | — | 1 | 5.98 |
| CHEMBL4467660 | — | — | 1 | 5.92 |
| CHEMBL4575972 | — | — | 1 | 5.92 |
| CHEMBL3981698 | — | — | 1 | 5.89 |
| CHEMBL4454726 | — | — | 1 | 5.88 |
| CHEMBL3392484 | — | — | 1 | 5.44 |
| CHEMBL4582242 | — | — | 1 | 5.41 |
| CHEMBL4440697 | — | — | 1 | 5.41 |
| CHEMBL4444789 | — | — | 1 | 5.38 |
| CHEMBL4582717 | — | — | 1 | 5.34 |
| CHEMBL257234 | — | — | 1 | 5.31 |
| CHEMBL4547694 | — | — | 1 | 5.26 |
| CHEMBL4571585 | — | — | 1 | 5.24 |
| CHEMBL4468491 | — | — | 1 | 5.21 |
| CHEMBL4465108 | — | — | 1 | 5.21 |
| CHEMBL4530675 | — | — | 1 | 5.18 |
| CHEMBL4471411 | — | — | 1 | 5.18 |
| CHEMBL3948213 | — | — | 1 | 5.16 |
| CHEMBL3392552 | — | — | 1 | 5.16 |
| CHEMBL3966573 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559294 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4516514 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4543065 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4539074 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4457949 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4571524 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4573731 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4466017 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4532036 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4514413 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4580349 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4467660 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4575972 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3981698 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4454726 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3392484 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4582242 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4440697 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4444789 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4582717 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL257234 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4547694 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4571585 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4468491 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4465108 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4530675 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4471411 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3948213 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3392552 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3966573 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL397804 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4562864 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL257286 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4586764 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3941648 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4448798 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3633431 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4569197 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4551803 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL1321754 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4593835 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1235568 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL1095743 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3956684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4561485 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4468867 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4442283 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4443754 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4474760 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1866173 | — | IC50 | > | 200000.0 | nM | - |