Assay Detail
Functional
CHEMBL4370283
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.02 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569885 | — | — | 1 | 7.72 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.75 |
| CHEMBL4546122 | — | — | 1 | 6.37 |
| CHEMBL4572443 | — | — | 1 | 6.28 |
| CHEMBL4552482 | — | — | 1 | 6.22 |
| CHEMBL4473768 | — | — | 1 | 6.11 |
| CHEMBL4473422 | — | — | 1 | 5.96 |
| CHEMBL4541014 | — | — | 1 | 5.64 |
| CHEMBL4460381 | — | — | 1 | 5.29 |
| CHEMBL4520163 | — | — | 1 | 5.06 |
| CHEMBL4475082 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569885 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4546122 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4572443 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4552482 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4473768 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4473422 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4541014 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4460381 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4520163 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4475082 | — | IC50 | = | 13500.0 | nM | 4.87 |