Assay Detail
Functional
CHEMBL4370285
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569885 | — | — | 1 | 7.70 |
| CHEMBL4546122 | — | — | 1 | 7.22 |
| CHEMBL4552482 | — | — | 1 | 7.06 |
| CHEMBL4572443 | — | — | 1 | 6.82 |
| CHEMBL4460381 | — | — | 1 | 6.68 |
| CHEMBL4473768 | — | — | 1 | 6.60 |
| CHEMBL4541014 | — | — | 1 | 6.46 |
| CHEMBL4475082 | — | — | 1 | 5.72 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.51 |
| CHEMBL4520163 | — | — | 1 | 5.48 |
| CHEMBL4473422 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569885 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4546122 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4552482 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4572443 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4460381 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4473768 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4541014 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4475082 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4520163 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4473422 | — | IC50 | = | 6300.0 | nM | 5.20 |