Assay Detail
Binding
CHEMBL4370288
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Inhibition of bovine brain tubulin polymerization after 20 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.51 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569885 | — | — | 1 | 6.15 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL4473768 | — | — | 1 | 5.60 |
| CHEMBL4572443 | — | — | 1 | 5.60 |
| CHEMBL4546122 | — | — | 1 | 5.55 |
| CHEMBL4552482 | — | — | 1 | 5.48 |
| CHEMBL4541014 | — | — | 1 | 5.00 |
| CHEMBL4460381 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569885 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4473768 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4572443 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4546122 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4552482 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4541014 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4460381 | — | IC50 | = | 18000.0 | nM | 4.75 |