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Assay Detail

CHEMBL4370313

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Functional
Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16
Confidence 1 — Organism
Curated By Autocuration

Target

B16 (CHEMBL381)
Type CELL-LINE
Organism Mus musculus

Publication

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Romagnoli R, Prencipe F, Oliva P, Baraldi S, Baraldi PG, Schiaffino Ortega S, Chayah M, Kimatrai Salvador M, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Mattiuzzo E, Viola G.
J Med Chem (2019) 62 : 1274 -1290
PubMed 30633509 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.63 7.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4569885 1 7.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4569885 IC50 = 23.4 nM 7.63