Assay Detail
Binding
CHEMBL4370539
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Inhibition of full length human menin/FAM-tagged MLL1 (unknown origin) protein-protein interaction after 15 mins by fluorescence polarization assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.96 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586090 | — | — | 1 | 6.93 |
| CHEMBL4533143 | — | — | 1 | 5.67 |
| CHEMBL4442317 | — | — | 1 | 4.99 |
| CHEMBL4580675 | — | — | 1 | 4.76 |
| CHEMBL4530202 | — | — | 1 | 4.61 |
| CHEMBL4593261 | — | — | 1 | 4.51 |
| CHEMBL4526830 | — | — | 1 | 4.46 |
| CHEMBL4474185 | — | — | 1 | 4.43 |
| CHEMBL4437554 | — | — | 1 | 4.29 |
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | - |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
| CHEMBL4440500 | — | — | 1 | - |
| CHEMBL4569986 | — | — | 1 | - |
| CHEMBL4447074 | — | — | 1 | - |
| CHEMBL4589914 | — | — | 1 | - |
| CHEMBL4520948 | — | — | 1 | - |
| CHEMBL4550942 | — | — | 1 | - |
| CHEMBL4558443 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586090 | — | IC50 | = | 118.3 | nM | 6.93 |
| CHEMBL4533143 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4442317 | — | IC50 | = | 10240.0 | nM | 4.99 |
| CHEMBL4580675 | — | IC50 | = | 17330.0 | nM | 4.76 |
| CHEMBL4530202 | — | IC50 | = | 24730.0 | nM | 4.61 |
| CHEMBL4593261 | — | IC50 | = | 30940.0 | nM | 4.51 |
| CHEMBL4526830 | — | IC50 | = | 34540.0 | nM | 4.46 |
| CHEMBL4474185 | — | IC50 | = | 36930.0 | nM | 4.43 |
| CHEMBL4437554 | — | IC50 | = | 50750.0 | nM | 4.29 |
| CHEMBL3786182 | GSK2879552 | IC50 | - | — | - | |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | - | — | - | |
| CHEMBL4440500 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4569986 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4447074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4589914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4520948 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4550942 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4558443 | — | IC50 | > | 100000.0 | nM | - |