Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4370540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAOA (unknown origin) by Promega MAO-Glo assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.
Wang X, Su M, Li Y, Liu T, Wang Y, Chen Y, Tang L, He YP, Ding X, Yu F, Shen J, Li J, Zhou Y, Chen YL, Xiong B.
Bioorg Med Chem Lett (2019) 29 : 844 -847
PubMed 30713023 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.92 5.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3989843 TRANYLCYPROMINE 4.0 1 5.99
CHEMBL4580675 1 5.65
CHEMBL4520948 1 5.39
CHEMBL4437554 1 5.34
CHEMBL4526830 1 5.08
CHEMBL4550942 1 5.07
CHEMBL4569986 1 5.04
CHEMBL4442317 1 4.90
CHEMBL4447074 1 4.89
CHEMBL4558443 1 4.68
CHEMBL4593261 1 4.68
CHEMBL4533143 1 4.39
CHEMBL4589914 1 4.32
CHEMBL4440500 1 4.25
CHEMBL4474185 1 4.18
CHEMBL4530202 1 -
CHEMBL3586090 1 -
CHEMBL3786182 GSK2879552 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3989843 TRANYLCYPROMINE IC50 = 1020.0 nM 5.99
CHEMBL4580675 IC50 = 2230.0 nM 5.65
CHEMBL4520948 IC50 = 4100.0 nM 5.39
CHEMBL4437554 IC50 = 4550.0 nM 5.34
CHEMBL4526830 IC50 = 8270.0 nM 5.08
CHEMBL4550942 IC50 = 8570.0 nM 5.07
CHEMBL4569986 IC50 = 9190.0 nM 5.04
CHEMBL4442317 IC50 = 12460.0 nM 4.90
CHEMBL4447074 IC50 = 12890.0 nM 4.89
CHEMBL4558443 IC50 = 20990.0 nM 4.68
CHEMBL4593261 IC50 = 20790.0 nM 4.68
CHEMBL4533143 IC50 = 40860.0 nM 4.39
CHEMBL4589914 IC50 = 47470.0 nM 4.32
CHEMBL4440500 IC50 = 56440.0 nM 4.25
CHEMBL4474185 IC50 = 65880.0 nM 4.18
CHEMBL4530202 IC50 > 100000.0 nM -
CHEMBL3586090 IC50 - -
CHEMBL3786182 GSK2879552 IC50 > 100000.0 nM -