Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4370542

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.
Wang X, Su M, Li Y, Liu T, Wang Y, Chen Y, Tang L, He YP, Ding X, Yu F, Shen J, Li J, Zhou Y, Chen YL, Xiong B.
Bioorg Med Chem Lett (2019) 29 : 844 -847
PubMed 30713023 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.59 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4442317 1 6.54
CHEMBL4474185 1 6.31
CHEMBL4533143 1 6.29
CHEMBL4589914 1 5.70
CHEMBL4437554 1 5.60
CHEMBL3586090 1 5.58
CHEMBL4520948 1 5.53
CHEMBL4530202 1 5.47
CHEMBL4447074 1 5.44
CHEMBL4550942 1 5.26
CHEMBL4569986 1 5.22
CHEMBL4558443 1 5.16
CHEMBL4526830 1 5.14
CHEMBL4580675 1 4.95
CHEMBL4593261 1 -
CHEMBL4440500 1 -
CHEMBL3989843 TRANYLCYPROMINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4442317 IC50 = 290.0 nM 6.54
CHEMBL4474185 IC50 = 490.0 nM 6.31
CHEMBL4533143 IC50 = 510.0 nM 6.29
CHEMBL4589914 IC50 = 2010.0 nM 5.70
CHEMBL4437554 IC50 = 2490.0 nM 5.60
CHEMBL3586090 IC50 = 2600.0 nM 5.58
CHEMBL4520948 IC50 = 2960.0 nM 5.53
CHEMBL4530202 IC50 = 3420.0 nM 5.47
CHEMBL4447074 IC50 = 3600.0 nM 5.44
CHEMBL4550942 IC50 = 5550.0 nM 5.26
CHEMBL4569986 IC50 = 5970.0 nM 5.22
CHEMBL4558443 IC50 = 6960.0 nM 5.16
CHEMBL4526830 IC50 = 7310.0 nM 5.14
CHEMBL4580675 IC50 = 11360.0 nM 4.95
CHEMBL4593261 IC50 > 100000.0 nM -
CHEMBL4440500 IC50 > 100000.0 nM -
CHEMBL3989843 TRANYLCYPROMINE IC50 > 100000.0 nM -