Assay Detail
Binding
CHEMBL4370792
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Inhibition of PI3K in rat Rat-1 cells assessed as decrease in AKT 1/2 phosphorylation at ser473 residues after 1 hr by AlphaScreen assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643409 | — | — | 1 | 7.33 |
| CHEMBL3643349 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643409 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3643349 | — | IC50 | = | 153.0 | nM | 6.82 |