Assay Detail
ADMET
CHEMBL4370798
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Antiproliferative activity against anti-IgM antibody-stimulated BALB/c mouse B cells after 2 days by Alamar Blue reagent-based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | B-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.96 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453747 | — | — | 1 | 8.49 |
| CHEMBL4528263 | — | — | 1 | 8.32 |
| CHEMBL4554894 | — | — | 1 | 8.15 |
| CHEMBL4530810 | — | — | 1 | 8.10 |
| CHEMBL4518787 | — | — | 1 | 7.92 |
| CHEMBL4467692 | — | — | 1 | 7.77 |
| CHEMBL4581474 | — | — | 1 | 7.62 |
| CHEMBL4514389 | — | — | 1 | 7.62 |
| CHEMBL3643349 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453747 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4528263 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4554894 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4530810 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4518787 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4467692 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4581474 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4514389 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3643349 | — | IC50 | = | 24.0 | nM | 7.62 |