Assay Detail
Binding
CHEMBL4370834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human N-terminal His6-tagged NAF1 expressed in Escherichia coli by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
CDGSH iron-sulfur domain-containing protein 2 (CHEMBL4523399) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.16 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.64 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 5.32 |
| CHEMBL602048 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL602048 | — | IC50 | = | 29770.0 | nM | 4.53 |