Assay Detail
Binding
CHEMBL4371111
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Inhibition of His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.51 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434792 | — | — | 1 | 9.10 |
| CHEMBL2170427 | — | — | 1 | 8.43 |
| CHEMBL2170597 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434792 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2170427 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2170597 | — | IC50 | = | 10.0 | nM | 8.00 |